The product was originally conceived by its developer Dr. Alexander Riftine for navy purpose.

R&D was started at January 1980 and between 1981 and 1982 the first trial version of the product was developed based on the Time Domain and Auto-regression Function approach. By 1982 it became clear that the Time Domain approach was fundamentally flawed as it didn't reflect the internal structure of the heart rhythm. It was also revealed that the probability of erroneous assessments was no less than 30%, which was unacceptable.

In 1982 a new trial version was developed based on the Frequency Domain approach.

In 1982 a massive data collection effort was started, and by the summer of 1986 12000 samples of Orthostatic test data and 700 samples of Stress test data were collected and analyzed. One of the results of this analysis was a proprietary Classification of the Transitional Periods during Orthostatic test, developed in 1986.

To provide a meaningful and systematic interpretation for his entire collection of data, Dr. Riftine started searching for a fundamentally new methodology that would be more comprehensive and precise in measuring the individual's current physical/physiological state as well as health resource and genetic ability.

In the first part of 1987, Dr. Riftine formulated a novel theory for the quantitative assessment of the individual's functional state - Fitness Score utilizing Spectral analysis of R-R intervals variability methodology. This theory was based on Dr. Riftine's original ideas in the field of Bio-medical Cybernetics and Normal Physiology. The practical applications of the theory - specifically, its proprietary algorithms for the quantitative assessment of the individual's Fitness Score were developed on the basis of Marvin Minsky's Frame Theory.

The first product based on Dr. Riftine's new theory, Health-Express, was developed by 1988. It provided assessment of the level of Physical Fitness. The marketing campaign for Health-Express was launched in 1988.

In 1992 a new product, Nerve-Express, was launched. .Nerve-Express also dealt with the problem of reducing all possible variations of all Spectral function components (around 20-30) into a quantitative relationship between only two parameters: SNS and PSNS.
Nerve-Express is the first and only system to solve this problem of SNS-PSNS quantification. This technological breakthrough is achieved by the application of Dr. Riftine's proprietary algorithms. At 1994 was started clinical studies in Cornell Medical Center by using the Nerve-Express device and in 1996 it was used in Columbia University during study conducted by Dr. Mehmet OZ. From 1997 to 2000 a validation study of Nerve-Express was conducted by J. Thomas Bigger, Jr., M.D., Head of Research Holter Laboratory, at Columbia University College of Physicians and Surgeons.

In 1998 a "real-time" (up to 48 hours) Autonomic assessment was added to Nerve-Express.

In May of 2001 the European registration (CE mark) for Nerve-Express was granted and in August of 2001 Nerve-Express was launched on the European market.

In 2003 another test was added - the Valsalva maneuver combined with Deep Breathing.                                                                       
2004 it's became compatible with ambulatory Holter-Monitor for 24-hour Autonomic assessment with possibility to see on one page difference between "sleep" time and "awake" time.

2008 it's became compatible with PBI PC ECG device which enable to see one lead ECG on the screen and printout after words any part of ECG.

2010 US Patent "Quantitative assessment of Autonomic function based on Heart Rate Variability" is granted.

2010 Wireless Bluetooth device Zephyr HxM added to the list of compatible devices.

2011 Corscience, GMBx ECG wireless Bluetooth device added to the list of devices.

2014 Us Patent Fitness Score assessment during Orthostatic intervention was granted.

January 2020 Firstbeat Bodyguard 2 device implemented into the new Nerve-Express version 7.1 for 24-h ANS assessment to evaluate quality of Sleep time.

May 2021 new technological breakthrough was implemented - direct Polar belt connections to the computer with Windows 10 by Bluetooth Low energy (BLE) method, which revolutionize data input process. As result 2 new systems became available: - Dynamic Express and Horse Express.